Introduction Paracetamol is one of the most used medicines worldwide and is the most
common important poisoning in high-income countries. In overdose, paracetamol causes …

Acetaminophen is a commonly used analgesic and antipyretic agent and in recommended
therapeutic doses, is safe in healthy individuals. Because of wide availability and minimal …

Background: Acetaminophen is widely used as first-line therapy for chronic pain because of
its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it …

Liver injury and acute liver failure caused by an acetaminophen (APAP) overdose is a
significant clinical problem in western countries. With the introduction of the mouse model of …

Bone defect is a common clinical symptom which can arise from various causes. Currently,
bone tissue engineering has demonstrated positive therapeutic effects for bone defect repair …

Background Previous studies of paracetamol overdose treatment show that a 2-bag, 20-h
intravenous (IV) acetylcysteine regimen decreased the incidence of non-allergic …

Introduction Fifty years ago, basic scientific studies and the availability of assay methods
made the assessment of risk in paracetamol (acetaminophen) poisoning possible. The use …

Circulating microRNAs are biomarkers reported to be stable and translational across
species. MicroRNA-122 (miR-122) is a hepatocyte-specific microRNA biomarker for drug …

Abstract Background The POP Trial was a phase 1, open-label, rising-dose, randomised
study that explored the safety and tolerability of calmangafodipir (superoxide dismutase …

Background and Objectives: Over-the-counter availability and a good safety profile make
paracetamol one of the most common analgesics in developed countries but also the …