Human vitreous in proliferative diabetic retinopathy: characterization and translational implications
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …
age population. DR is a progressive eye disease caused by long-term accumulation of …
Implication of hyperhomocysteinemia in blood retinal barrier (BRB) dysfunction
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has
been linked to different systemic and neurological diseases, well-known as a risk factor for …
been linked to different systemic and neurological diseases, well-known as a risk factor for …
[HTML][HTML] Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
JR Tribble, A Otmani, S Sun, SA Ellis, G Cimaglia… - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …
Death of retinal neurons in streptozotocin-induced diabetic mice
PM Martin, P Roon, TK Van Ells… - … & visual science, 2004 - iovs.arvojournals.org
purpose. Neuronal cell death has been reported in retinas of humans with diabetic
retinopathy and in diabetic rat models. Little is known about neuronal cell death in mouse …
retinopathy and in diabetic rat models. Little is known about neuronal cell death in mouse …
Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity
Homocysteine (Hcy), produced physiologically in all cells, is an intermediate metabolite of
methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in …
methionine and cysteine metabolism. Hyperhomocysteinemia (HHcy) resulting from an in …
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4
CN Roybal, S Yang, CW Sun, D Hurtado… - Journal of biological …, 2004 - ASBMB
Vascular endothelial growth factor (VEGF) plays a key role in the development and
progression of diabetic retinopathy. We previously demonstrated that amino acid deprivation …
progression of diabetic retinopathy. We previously demonstrated that amino acid deprivation …
Homocysteine as a risk factor for nephropathy and retinopathy in type 2 diabetes
HC Looker, A Fagot-Campagna, EW Gunter… - Diabetologia, 2003 - Springer
Aims/hypothesis The aim of this study was to examine the relation between serum total
homocysteine concentrations and microvascular complications in Pima Indians with Type 2 …
homocysteine concentrations and microvascular complications in Pima Indians with Type 2 …
Pink1-mediated chondrocytic mitophagy contributes to cartilage degeneration in osteoarthritis
HJ Shin, H Park, N Shin, HH Kwon, Y Yin… - Journal of clinical …, 2019 - mdpi.com
Cartilage loss is a central event in the pathogenesis of osteoarthritis (OA), though other than
mechanical loading, the biochemical mechanisms underlying OA pathology remain poorly …
mechanical loading, the biochemical mechanisms underlying OA pathology remain poorly …
The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients
A Dietrich-Muszalska, J Malinowska, B Olas… - Neurochemical …, 2012 - Springer
The mechanisms of oxidative stress in schizophrenic patients are not fully understood. In the
present study, we investigated the effect of elevated level of homocysteine (Hcys) on some …
present study, we investigated the effect of elevated level of homocysteine (Hcys) on some …
Homocysteine: a potential biomarker for diabetic retinopathy
Diabetic retinopathy (DR) is the most common cause of blindness in people under the age of
65. Unfortunately, the current screening process for DR restricts the population that can be …
65. Unfortunately, the current screening process for DR restricts the population that can be …