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Childhood brain tumors: current management, biological insights, and future directions: JNSPG 75th Anniversary Invited Review Article
IF Pollack, S Agnihotri, A Broniscer - Journal of Neurosurgery: Pediatrics, 2019 - thejns.org
Brain tumors are the most common solid tumors in children, and, unfortunately, many
subtypes continue to have a suboptimal long-term outcome. During the last several years …
subtypes continue to have a suboptimal long-term outcome. During the last several years …
Medulloblastoma
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
The whole-genome landscape of medulloblastoma subtypes
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the develo** child, and highlight the need for molecularly targeted …
debilitating effects on the develo** child, and highlight the need for molecularly targeted …
Resolving medulloblastoma cellular architecture by single-cell genomics
Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …
molecular subgroups. Whereas genomic characteristics of these subgroups are well …
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study
Background International consensus recognises four medulloblastoma molecular
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …
variables pertaining to age, presence of metastases, extent of resection, histological …
Medulloblastomics revisited: biological and clinical insights from thousands of patients
Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …
Outcomes by clinical and molecular features in children with medulloblastoma treated with risk-adapted therapy: results of an international phase III trial (SJMB03)
PURPOSE SJMB03 (ClinicalTrials. gov identifier: NCT00085202) was a phase III risk-
adapted trial that aimed to determine the frequency and clinical significance of biological …
adapted trial that aimed to determine the frequency and clinical significance of biological …
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Background Patients with incomplete surgical resection of medulloblastoma are
controversially regarded as having a marker of high-risk disease, which leads to patients …
controversially regarded as having a marker of high-risk disease, which leads to patients …
Vismodegib exerts targeted efficacy against recurrent sonic hedgehog–subgroup medulloblastoma: results from phase II pediatric brain tumor consortium studies …
Purpose Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH)
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …