All living organisms rely on nutrients to sustain cell metabolism and energy production,
which in turn need to be adjusted based on available resources. The evolutionarily …

Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …

A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …

A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …

iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

We studied the relationship between growth rate and genome-wide gene expression, cell
cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by …

Genomic data allow the large-scale manual or semi-automated assembly of metabolic
network reconstructions, which provide highly curated organism-specific knowledge bases …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

Background The term 'metabolome'was introduced to the scientific literature in September
1998. Aim and key scientific concepts of the review To mark its 18-year-old 'coming of age' …