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TOR signaling and nutrient sensing
T Dobrenel, C Caldana, J Hanson… - Annual review of …, 2016 - annualreviews.org
All living organisms rely on nutrients to sustain cell metabolism and energy production,
which in turn need to be adjusted based on available resources. The evolutionarily …
which in turn need to be adjusted based on available resources. The evolutionarily …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …
both short-term changes during their lifetime and longer-term changes across generations …
Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria
S Hui, JM Silverman, SS Chen, DW Erickson… - Molecular systems …, 2015 - embopress.org
A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …
to the environment. Here, we study gene expression response to metabolic challenges in …
Development of a robust and repeatable UPLC− MS method for the long-term metabolomic study of human serum
E Zelena, WB Dunn, D Broadhurst… - Analytical …, 2009 - ACS Publications
A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …
developed based on protein precipitation followed by Ultra Performance Liquid …
Addressing accuracy and precision issues in iTRAQ quantitation
iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …
that allows quantitative comparison of protein abundance by measuring peak intensities of …
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
We studied the relationship between growth rate and genome-wide gene expression, cell
cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by …
cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by …
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
Genomic data allow the large-scale manual or semi-automated assembly of metabolic
network reconstructions, which provide highly curated organism-specific knowledge bases …
network reconstructions, which provide highly curated organism-specific knowledge bases …
Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …
The metabolome 18 years on: a concept comes of age
Background The term 'metabolome'was introduced to the scientific literature in September
1998. Aim and key scientific concepts of the review To mark its 18-year-old 'coming of age' …
1998. Aim and key scientific concepts of the review To mark its 18-year-old 'coming of age' …