In the beginning of the 21st century, the frequency of antimicrobial resistance (AMR) has
reached an apex, where even 4th and 5th generation antibiotics are becoming useless in …

Nutritional immunity is a form of innate immunity widespread in both vertebrates and
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …

Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that
underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa …

The ability of the human immune system to generate antibodies to any given antigen can be
strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous …

Although computational structure prediction has had great successes in recent years, it
regularly fails to predict the interactions of large protein complexes with residue-level …

Humans frequently encounter Staphylococcus aureus (SA) throughout life. Animal studies
have yielded SA candidate vaccines, yet all human SA vaccine trials have failed. One …

The opportunistic pathogen Staphylococcus aureus has become a major threat for human
health and well-being by develo** resistance to antibiotics and by fast evolution into new …

Staphylococcus aureus (SA) is a leading cause of bacterial infection and antibiotic
resistance globally. Therefore, development of an effective vaccine has been a major goal of …

Staphylococcus aureus represents a serious infectious threat to global public health and a
vaccine against S. aureus represents an unmet medical need. We here characterise two S …