Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

Cells coordinate intracellular activities in response to changes in the extracellular
environment to maximize their probability of survival and proliferation. Eukaryotic cells need …

Transcription factors canonically bind nucleosome-free DNA, making the positioning of
nucleosomes within regulatory regions crucial to the regulation of gene expression. Using …

The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of
cellular processes and are often deregulated in disease states. One major mode of action for …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

The human fungal pathogen Cryptococcus neoformans is characterized by its ability to
induce a distinct polysaccharide capsule in response to a number of host-specific …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

The rapid activation of gene expression in response to stimuli occurs largely through the
regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

Regulation of the cellular volume is fundamental for cell survival and function. Deviations
from equilibrium trigger dedicated signaling and transcriptional responses that mediate …