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[HTML][HTML] The aging lung: Physiology, disease, and immunity
The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …
[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …
Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study
GBD 2019 Ageing Collaborators - bmj, 2022 - bmj.com
Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study
2019 (GBD 2019) to estimate mortality and disability trends for the population aged≥ 70 …
2019 (GBD 2019) to estimate mortality and disability trends for the population aged≥ 70 …
Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
The quest to slow ageing through drug discovery
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
Facing up to the global challenges of ageing
Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …
people experience little ill health, a trait that should be extended to the general population …
Reversal of epigenetic aging and immunosenescent trends in humans
Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …
The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
[HTML][HTML] Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …