The immunology of multiple sclerosis

KE Attfield, LT Jensen, M Kaufmann… - Nature Reviews …, 2022 - nature.com
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Environmental and genetic risk factors for MS: an integrated review

E Waubant, R Lucas, E Mowry, J Graves… - Annals of clinical …, 2019 - Wiley Online Library
Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

[HTML][HTML] Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota

F Cignarella, C Cantoni, L Ghezzi, A Salter, Y Dorsett… - Cell metabolism, 2018 - cell.com
Multiple sclerosis (MS) is more common in western countries with diet being a potential
contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and …

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

T Olsson, LF Barcellos, L Alfredsson - Nature Reviews Neurology, 2017 - nature.com
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

Epidemiology of multiple sclerosis: from risk factors to prevention—an update

A Ascherio, KL Munger - Seminars in neurology, 2016 - thieme-connect.com
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Vitamin D and multiple sclerosis: An update

C Pierrot-Deseilligny, JC Souberbielle - Multiple sclerosis and related …, 2017 - Elsevier
The most recent findings linking exposure to sun and vitamin D insufficiency to multiple
sclerosis (MS) are reviewed. Due to insufficient sunshine and changing lifestyles …

Lifestyle and environmental factors in multiple sclerosis

L Alfredsson, T Olsson - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

MP Amato, T Derfuss, B Hemmer… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of
the central nervous system (CNS), most likely autoimmune in origin, usually beginning in …

Effects of dietary restriction on neuroinflammation in neurodegenerative diseases

L Fontana, L Ghezzi, AH Cross, L Piccio - Journal of Experimental …, 2021 - rupress.org
Recent and accumulating work in experimental animal models and humans shows that diet
has a much more pervasive and prominent role than previously thought in modulating …

Multiple sclerosis pathogenesis and updates in targeted therapeutic approaches

ES Vasileiou, KC Fitzgerald - Current allergy and asthma reports, 2023 - Springer
Abstract Purpose of Review In this review, we provide a comprehensive update on current
scientific advances and emerging therapeutic approaches in the field of multiple sclerosis …