Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

Mouse embryonic stem cells (mESCs) are clonal populations derived from preimplantation
mouse embryos that can be propagated in vitro and, when placed into blastocysts …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Of paramount importance for the development of cell therapies to treat diabetes is the
production of sufficient numbers of pancreatic endocrine cells that function similarly to …

The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety
of organs has generated much excitement over the possible use of hES cells in therapeutic …