Neuron–oligodendroglial interactions in health and malignant disease
Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …
Autonomous rhythmic activity in glioma networks drives brain tumour growth
Diffuse gliomas, particularly glioblastomas, are incurable brain tumours. They are
characterized by networks of interconnected brain tumour cells that communicate via Ca2+ …
characterized by networks of interconnected brain tumour cells that communicate via Ca2+ …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair
Human pluripotent stem cells (PSCs) represent an attractive source of cardiomyocytes with
potential applications including disease modeling, drug discovery and safety screening, and …
potential applications including disease modeling, drug discovery and safety screening, and …
A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells
The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the
primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that …
primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that …
What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
Cardiac pacemaker activity and aging
A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …
Pharmacologic approach to sinoatrial node dysfunction
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells
JJ Kim, L Yang, B Lin, X Zhu, B Sun, AD Kaplan… - Journal of molecular and …, 2015 - Elsevier
Background and objectives. The creation of cardiomyocytes derived from human induced
pluripotent stem cells (hiPS-CMs) has spawned broad excitement borne out of the prospects …
pluripotent stem cells (hiPS-CMs) has spawned broad excitement borne out of the prospects …
Induced pluripotent stem cell–derived cardiomyocytes provide in vivo biological pacemaker function
S Chauveau, EP Anyukhovsky, M Ben-Ari… - Circulation …, 2017 - Am Heart Assoc
Background—Although multiple approaches have been used to create biological
pacemakers in animal models, induced pluripotent stem cell–derived cardiomyocytes (iPSC …
pacemakers in animal models, induced pluripotent stem cell–derived cardiomyocytes (iPSC …