Neuroinflammation is implicated in the pathophysiology of a growing number of human
disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic …

Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …

Background Quantitative in vivo imaging of myelin loss and repair in patients with multiple
sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate …

In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …

Introduction Quantitative in vivo measurement of brain amyloid burden is important for both
research and clinical purposes. However, the existence of multiple imaging tracers presents …

Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …

Abstract Purpose of Review The purpose of this review is to discuss the interaction between
aging, progressive disease course, disability worsening, and treatment strategies in multiple …

Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of
brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool …

Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …

Abstract Study Objectives Previous studies found that sleep loss can suppress the
expression of genes implicated in myelination and can have adverse effects on …