Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …

In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant
bone loss. Although oestrogen normally counteracts excessive bone resorption by …

Core body temperature changes across the ovulatory menstrual cycle, such that it is 0.3° C
to 0.7° C higher in the post-ovulatory luteal phase when progesterone is high compared with …

Precise timing in hormone release from the hypothalamus, the pituitary and ovary is critical
for fertility. Hormonal release patterns of the reproductive axis are regulated by a feedback …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

Most organisms evolved endogenous, so called circadian clocks as internal timekee**
mechanisms allowing them to adapt to recurring changes in environmental demands …

Simple Summary In mammals, circadian rhythms in nearly all behaviors and physiological
processes are controlled by the suprachiasmatic nucleus, a collection of neurons in the …

The central circadian clock of the suprachiasmatic nucleus (SCN) is a network consisting of
various types of neurons and glial cells. Individual cells have the autonomous molecular …