The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B
lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage'inappropriate'genes and …

The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in
B cell development. Here we show that E2A and EBF1 bound regulatory elements present in …

The expression of lineage-associated genes, as well as the survival and expansion of
committed B cell progenitors, is controlled by multiple transcriptional regulators and growth …

Abstract The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate'decisions' in
diverse systems. Here we show that Foxo1-dependent gene expression was critical at many …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

E and inhibitor of DNA binding (ID) proteins are transcriptional regulators that function in
many developmental processes in vertebrates and invertebrates. One subset of E proteins …

The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …

The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at
the pre-pro-B cell stage in E2A-deficient mice. Here, we demonstrate by conditional …