What is known and objective Statins are widely used worldwide in the prevention and
treatment of coronary atherosclerotic heart disease and ischaemic stroke. However, in …

Background: Statins are the most widely used lipid-lowering agents for patients with
hyperlipidemia. However, interindividual variations in efficacy and risk of adverse drug …

Objective Statins are the first-choice therapy for dyslipidemia, but their effectiveness can be
influenced by genetic polymorphisms. This study was conducted to assess the association of …

Background Dyslipidemia is a predisposing factor for coronary heart disease (CHD). High-
intensity statin therapy is recommended as secondary prevention. ABCB1 and SLCO1B1 …

Simvastatin (brand name Zocor) is a member of the statin class of drugs, used to regulate
low-density lipoprotein (LDL) cholesterol levels in various conditions, including familial …

OBJECTIVE: To report a possible pharmacogenomics (PGx)-related, cognitive dysfunction,
adverse drug reaction from methotrexate (MTX) that may be multifactorial in origin …

Due to the diverse genetic characteristics of metabolism and high drug plasma exposure,
great inter-subject variability exists in the clinical efficacy and incidence of adverse events …

We searched the PubMed database (1966 to July 2021) using the following keyword
strategies: SLCO1B1:(simvastatin OR rosuvastatin OR pravastatin OR pitavastatin OR …

Many xenobiotic and endogenous compounds are transported from blood into hepatocytes
mediated by organic anion transporter protein (OATP1B1), which is encoded by solute …

Background APOE and SLCO1B1 genetic polymorphisms are relevant in statin
pharmacokinetics. Objective Aim of this study was to investigate the polymorphisms of APOE …