The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise
because of their low risk of insertional mutagenesis, high potency, accelerated development …

SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …

Protein synthesis by ribosomes is critically important for gene expression in all cells.
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …

Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity,
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …

Throughout decades, the intrinsic power of the immune system to fight pathogens has
inspired researchers to develop techniques that enable the prevention or treatment of …

Knowing the 3D structures formed by the various conformations populating the RNA free-
energy landscape, their relative abundance, and kinetic interconversion rates is required to …

Sparse and short-lived excited RNA conformational states are essential players in cell
physiology, disease, and therapeutic development, yet determining their 3D structures …