A framework for designing delivery systems

W Poon, BR Kingston, B Ouyang, W Ngo… - Nature …, 2020 - nature.com
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing
and treating patients. Nanomaterials are promising vehicles to transport agents that include …

Designing nanotheranostics with machine learning

L Rao, Y Yuan, X Shen, G Yu, X Chen - Nature Nanotechnology, 2024 - nature.com
The inherent limits of traditional diagnoses and therapies have driven the development and
application of emerging nanotechnologies for more effective and safer management of …

The dose threshold for nanoparticle tumour delivery

B Ouyang, W Poon, YN Zhang, ZP Lin, BR Kingston… - Nature materials, 2020 - nature.com
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of
0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only …

Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment

Y Huang, X Guo, Y Wu, X Chen, L Feng, N **e… - … and Targeted Therapy, 2024 - nature.com
Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

A survey on applications of deep learning in microscopy image analysis

Z Liu, L **, J Chen, Q Fang, S Ablameyko, Z Yin… - Computers in biology …, 2021 - Elsevier
Advanced microscopy enables us to acquire quantities of time-lapse images to visualize the
dynamic characteristics of tissues, cells or molecules. Microscopy images typically vary in …

Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

Principles of nanoparticle delivery to solid tumors

WCW Chan - BME frontiers, 2023 - spj.science.org
The effective treatment of patients with cancer hinges on the delivery of therapeutics to a
tumor site. Nanoparticles provide an essential transport system. We present 5 principles to …

Nanotechnology for modern medicine: next step towards clinical translation

S Sindhwani, WCW Chan - Journal of Internal Medicine, 2021 - Wiley Online Library
The field of nanotechnology has been a significant research focus in the last thirty years.
This emphasis is due to the unique optical, electrical, magnetic, chemical and biological …

Deep learning meets nanophotonics: a generalized accurate predictor for near fields and far fields of arbitrary 3D nanostructures

PR Wiecha, OL Muskens - Nano letters, 2019 - ACS Publications
Deep artificial neural networks are powerful tools with many possible applications in
nanophotonics. Here, we demonstrate how a deep neural network can be used as a fast …

Specific endothelial cells govern nanoparticle entry into solid tumors

BR Kingston, ZP Lin, B Ouyang, P MacMillan, J Ngai… - ACS …, 2021 - ACS Publications
The successful delivery of nanoparticles to solid tumors depends on their ability to pass
through blood vessels and into the tumor microenvironment. Here, we discovered a subset …