[HTML][HTML] Articular fibrocartilage-Why does hyaline cartilage fail to repair?
Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …
Proteoglycans in articular cartilage and their contribution to chondral injury and repair mechanisms
L Alcaide-Ruggiero, R Cugat… - International journal of …, 2023 - mdpi.com
Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing
biomechanical properties crucial for its proper functioning. They are key players in chondral …
biomechanical properties crucial for its proper functioning. They are key players in chondral …
[BOOK][B] Microcomputed tomography: methodology and applications
SR Stock - 2019 - taylorfrancis.com
MicroComputed Tomography has become the gold standard for studying 3D microscopic
structures nondestructively, and this book provides up-to-date coverage of the modality. The …
structures nondestructively, and this book provides up-to-date coverage of the modality. The …
Subchondral bone remodeling: a therapeutic target for osteoarthritis
There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …
the development of osteoarthritis (OA). This review presents recent investigations on the …
Bioactive factors for cartilage repair and regeneration: improving delivery, retention, and activity
Articular cartilage is a remarkable tissue whose sophisticated composition and architecture
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
Navigating regulatory pathways for translation of biologic cartilage repair products
Long-term clinical repair of articular cartilage remains elusive despite advances in cartilage
tissue engineering. Only one cartilage repair therapy classified as a “cellular and gene …
tissue engineering. Only one cartilage repair therapy classified as a “cellular and gene …
Nanofibrous hyaluronic acid scaffolds delivering TGF-β3 and SDF-1α for articular cartilage repair in a large animal model
Focal cartilage injuries have poor intrinsic healing potential and often progress to
osteoarthritis, a costly disease affecting almost a third of adults in the United States. To treat …
osteoarthritis, a costly disease affecting almost a third of adults in the United States. To treat …
An overview of de novo bone generation in animal models
Some of the earliest success in de novo tissue generation was in bone tissue, and
advances, facilitated by the use of endogenous and exogenous progenitor cells, continue …
advances, facilitated by the use of endogenous and exogenous progenitor cells, continue …
A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage
Cartilage provides low-friction properties and plays an essential role in diarthrodial joints. A
hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen …
hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen …
In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug
J Kang, Y Li, Y Qin, Z Huang, Y Wu, L Sun, C Wang… - Nano-Micro Letters, 2024 - Springer
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration
such as a long-term repair effect and less deterioration compared to repairing cartilage …
such as a long-term repair effect and less deterioration compared to repairing cartilage …