NMR and metabolomics—A roadmap for the future
Metabolomics investigates global metabolic alterations associated with chemical, biological,
physiological, or pathological processes. These metabolic changes are measured with …
physiological, or pathological processes. These metabolic changes are measured with …
Quantitative NMR-based biomedical metabolomics: Current status and applications
Nuclear Magnetic Resonance (NMR) spectroscopy is a quantitative analytical tool
commonly utilized for metabolomics analysis. Quantitative NMR (qNMR) is a field of NMR …
commonly utilized for metabolomics analysis. Quantitative NMR (qNMR) is a field of NMR …
Predicting multiple conformations via sequence clustering and AlphaFold2
Abstract AlphaFold2 (ref.) has revolutionized structural biology by accurately predicting
single structures of proteins. However, a protein's biological function often depends on …
single structures of proteins. However, a protein's biological function often depends on …
Biological magnetic resonance data bank
Abstract The Biological Magnetic Resonance Data Bank (BMRB, https://bmrb. io) is the
international open data repository for biomolecular nuclear magnetic resonance (NMR) …
international open data repository for biomolecular nuclear magnetic resonance (NMR) …
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a
homopentameric cation channel that is important for virus pathogenicity. Here we report a …
homopentameric cation channel that is important for virus pathogenicity. Here we report a …
Atomic structure of the open SARS-CoV-2 E viroporin
The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone post-translational modifications (PTMs) are important for regulating various DNA-
templated processes. Here, we report the existence of a histone PTM in mammalian cells …
templated processes. Here, we report the existence of a histone PTM in mammalian cells …
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants
Despite the prominent role of the K-Ras protein in many different types of human cancer,
major gaps in atomic-level information severely limit our understanding of its functions in …
major gaps in atomic-level information severely limit our understanding of its functions in …
Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living
organisms. During Zn limitation, specialized enzymes called metallochaperones are …
organisms. During Zn limitation, specialized enzymes called metallochaperones are …