Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line
defenders in the anti-tumor response. To prevent tumor development, NK cells are …

Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to
microbes and tumors. Historically, their classification hinged on a limited array of surface …

The importance of metabolic pathways in regulating immune responses is now well
established, and a map** of the bioenergetic metabolism of different immune cell types is …

Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their
migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an …

Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during
infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare …

Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals.
Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and …

Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-
redundant roles in host protection against pathogens and cancer. Despite their circulating …

Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation
in cellular membranes. Within the last decade, physiological and pathological roles for …

Due to their intrinsic ability to eliminate malignant cells, natural killer (NK) cells emerge as a
promising immunotherapy for cancer. While clinical studies have affirmed the safety of NK …

Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype
driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our …