Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery
vehicles in both gene therapy studies and basic studies for gene function analysis due to …

Oncolytic viruses have been taking the front stage in biological therapy for cancer recently.
The first and most potent virus to be used in oncolytic virotherapy is human adenovirus …

Near-infrared fluorescent proteins (FPs) are in high demand for in vivo imaging. We
developed four spectrally distinct near-infrared FPs—iRFP670, iRFP682, iRFP702 and …

The consequences of human adenovirus (HAdV) infections are generally mild. However,
despite the perception that HAdVs are harmless, infections can cause severe disease in …

More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …

Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …

Visibly fluorescent proteins (FPs) from jellyfish and corals have revolutionized many areas of
molecular and cell biology, but the use of FPs in intact animals, such as mice, has been …

Adenoviruses have been studied intensively for over 50 years as models of virus–cell
interactions and latterly as gene vectors. With the advent of more sophisticated structural …