Fundamentals and methods for T‐and B‐cell epitope prediction

JL Sanchez-Trincado… - Journal of …, 2017 - Wiley Online Library
Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
develo** pathogen‐specific memory that confers immunological protection. Memory and …

[HTML][HTML] An overview of bioinformatics tools for epitope prediction: implications on vaccine development

RE Soria-Guerra, R Nieto-Gomez… - Journal of biomedical …, 2015 - Elsevier
Exploitation of recombinant DNA and sequencing technologies has led to a new concept in
vaccination in which isolated epitopes, capable of stimulating a specific immune response …

Designing of interferon-gamma inducing MHC class-II binders

SK Dhanda, P Vir, GPS Raghava - Biology direct, 2013 - Springer
Background The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T
helper cells play a substantial contribution in the control of infections such as caused by …

Transfer learning

SJ Pan - Learning, 2020 - api.taylorfrancis.com
Supervised machine learning techniques have already been widely studied and applied to
various real-world applications. However, most existing supervised algorithms work well …

NetMHCpan, a method for MHC class I binding prediction beyond humans

I Hoof, B Peters, J Sidney, LE Pedersen, A Sette… - Immunogenetics, 2009 - Springer
Binding of peptides to major histocompatibility complex (MHC) molecules is the single most
selective step in the recognition of pathogens by the cellular immune system. The human …

Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

M Nielsen, C Lundegaard, O Lund - BMC bioinformatics, 2007 - Springer
Abstract Background Antigen presenting cells (APCs) sample the extra cellular space and
present peptides from here to T helper cells, which can be activated if the peptides are of …

NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence

M Nielsen, C Lundegaard, T Blicher, K Lamberth… - PloS one, 2007 - journals.plos.org
Background Binding of peptides to Major Histocompatibility Complex (MHC) molecules is
the single most selective step in the recognition of pathogens by the cellular immune system …

Immunoinformatics and epitope prediction in the age of genomic medicine

L Backert, O Kohlbacher - Genome medicine, 2015 - Springer
Immunoinformatics involves the application of computational methods to immunological
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …

Machine learning techniques for the prediction of B-cell and T-cell epitopes as potential vaccine targets with a specific focus on SARS-CoV-2 pathogen: A review

SNH Bukhari, A Jain, E Haq, A Mehbodniya, J Webber - Pathogens, 2022 - mdpi.com
The only part of an antigen (a protein molecule found on the surface of a pathogen) that is
composed of epitopes specific to T and B cells is recognized by the human immune system …

A novel multi-epitope peptide vaccine against cancer: an in silico approach

N Nezafat, Y Ghasemi, G Javadi, MJ Khoshnoud… - Journal of theoretical …, 2014 - Elsevier
Cancer immunotherapy has an outstanding position in cancer prevention and treatment. In
this kind of therapy, the immune system is activated to eliminate cancerous cells. Multi …