Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …

Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and
propagating action potentials. Consistent with their physiological significance, dysfunction …

Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …

The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for develo** next-generation analgesics. A prominent characteristic of …

The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …

Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …

Na v 1.7 represents a preeminent target for next-generation analgesics for its critical role in
pain sensation. Here we report a 2.2-Å resolution cryo-EM structure of wild-type (WT) Na v …

Voltage-gated sodium (Nav) channel Nav1. 7 has been targeted for the development of
nonaddictive pain killers. Structures of Nav1. 7 in distinct functional states will offer an …

The sodium channel NaV1. 6 is widely expressed in neurons of the central and peripheral
nervous systems, which plays a critical role in regulating neuronal excitability. Dysfunction of …

Voltage-gated sodium channels (Nav) undergo conformational shifts in response to
membrane potential changes, a mechanism known as the electromechanical coupling. To …