On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA
Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA nucleotide modification
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to …
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
Techniques for systematically monitoring protein translation have lagged far behind
methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome …
methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome …
[HTML][HTML] Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes
The ability to sequence genomes has far outstripped approaches for deciphering the
information they encode. Here we present a suite of techniques, based on ribosome profiling …
information they encode. Here we present a suite of techniques, based on ribosome profiling …
[HTML][HTML] Correlation of mRNA and protein in complex biological samples
The correlation between mRNA and protein abundances in the cell has been reported to be
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein
abundance, underscoring the value of measuring gene expression at the level of translation …
abundance, underscoring the value of measuring gene expression at the level of translation …
Comparing protein abundance and mRNA expression levels on a genomic scale
Attempts to correlate protein abundance with mRNA expression levels have had variable
success. We review the results of these comparisons, focusing on yeast. In the process, we …
success. We review the results of these comparisons, focusing on yeast. In the process, we …
Global signatures of protein and mRNA expression levels
Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …
relationship between protein and mRNA expression levels informs about the combined …
The scanning mechanism of eukaryotic translation initiation
AG Hinnebusch - Annual review of biochemistry, 2014 - annualreviews.org
In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …
mechanism, wherein every triplet in the messenger RNA leader is inspected for …