Applications of nanobodies

S Muyldermans - Annual review of animal biosciences, 2021 - annualreviews.org
Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control

S Wang, W Li, Z Wang, W Yang, E Li, X **a… - Signal transduction and …, 2024 - nature.com
To adequately prepare for potential hazards caused by emerging and reemerging infectious
diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future …

Research progress and applications of nanobody in human infectious diseases

Y Mei, Y Chen, JP Sivaccumar, Z An, N **a… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises.
In addition to persistent infectious diseases such as malaria and dengue fever, the vicious …

Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatment

J Wang, G Kang, H Yuan, X Cao, H Huang… - Frontiers in …, 2022 - frontiersin.org
Recombinant antibodies such as nanobodies are progressively demonstrating to be a valid
alternative to conventional monoclonal antibodies also for clinical applications. Furthermore …

Nanobody in a Double “Y”-Shaped Assembly: A Promising Candidate for Lateral Flow Immunoassays

Y **ao, H Dong, C Wu, K Zhang, X Jiang… - Analytical …, 2024 - ACS Publications
Derived from camelid heavy-chain antibodies, nanobodies (Nbs) are the smallest natural
antibodies and are an ideal tool in biological studies because of their simple structure, high …

Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

J Gorman, CSF Cheung, Z Duan, L Ou, M Wang… - Nature …, 2024 - nature.com
Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …

A bispecific nanobody with high sensitivity/efficiency for simultaneous determination of carbaryl and its metabolite 1-naphthol in the soil and rice samples

M Liu, Z Chen, X Huang, H Wang, J Zhao, Y Shen… - Environmental …, 2023 - Elsevier
The simultaneous determination of carbaryl and its metabolite 1-naphthol is essential for risk
assessment of pesticide exposure in agricultural and environmental samples. Herein …

Perspectives of next-generation live-attenuated Rift Valley fever vaccines for animal and human use

PJ Wichgers Schreur, BH Bird, T Ikegami… - Vaccines, 2023 - mdpi.com
Live-attenuated Rift Valley fever (RVF) vaccines transiently replicate in the vaccinated host,
thereby effectively initiating an innate and adaptive immune response. Rift Valley fever virus …

Development of broad-spectrum nanobodies for the therapy and diagnosis of SARS-CoV-2 and its multiple variants

L He, Q Wu, Z Zhang, L Chen, K Yu, L Li… - Molecular …, 2024 - ACS Publications
The continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has evaded the efficacy of previously developed antibodies and vaccines, thus remaining …

An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies

A Das, R Ahmed, S Akhtar, K Begum, S Banu - Gene reports, 2021 - pmc.ncbi.nlm.nih.gov
Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions
caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus …