In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

The detailed understanding of the binding of small molecules to proteins is the key for the
development of novel drugs or to increase the acceptance of substrates by enzymes …

The lipid-sensing transcription factor PPARγ is the target of antidiabetic thiazolidinediones
(TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E …

Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal
cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the …

Chlorinated polyfluorinated ether sulfonates (Cl-PFAESs) are the alternative products of
perfluorooctanesulfonate (PFOS) in the metal plating industry in China. The similarity in …

The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-
tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 …

Here, we describe the identification and synthesis of novel indole sulfonamide derivatives
that activate the three peroxisome proliferator activated receptor (PPAR) isoforms. Starting …

Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their
molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified …

Fatty acid channeling into oxidation or storage modes depends on physiological conditions
and hormonal signaling. However, the directionality of this channeling may also depend on …