Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …

Objective The risk-benefit profile of antidepressant medications in bipolar disorder is
controversial. When conclusive evidence is lacking, expert consensus can guide treatment …

Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O'Donovan C,
MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Background Episodes of depression are the most frequent cause of disability among
patients with bipolar disorder. The effectiveness and safety of standard antidepressant …

Objectives. These guidelines are based on a first edition that was published in 2002, and
have been edited and updated with the available scientific evidence until September 2009 …

OBJECTIVE: This study reviewed the evidence from randomized, controlled trials on the
efficacy and safety of antidepressants in the short-term treatment of bipolar depression …

Objective: The authors examined the comparative risks of switches in mood polarity into
hypomania or mania during acute and continuation trials of adjunctive antidepressant …

Objective: The aim of this study was to evaluate the efficacy and tolerability of quetiapine
and paroxetine monotherapy for major depression in bipolar disorder. Method: 740 patients …

The 2002 American Psychiatric Association (APA) guidelines for the treatment of bipolar
disorder recommended more conservative use of antidepressants. This change in …