Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators …

An inverse association between cancer and neurodegeneration is plausible because these
biological processes share several genes and signaling pathways. Whereas uncontrolled …

Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …

Drug delivery systems based on calcium phosphate (CaP) coatings have been recently
recognized as beneficial drug delivery systems in complex cases of bone diseases for …

The protein kinase R (PKR, also called EIF2AK2) is an interferon-inducible double-stranded
RNA protein kinase with multiple effects on cells that plays an active part in the cellular …

Background Mammalian cells have developed multiple intracellular mechanisms to defend
against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP …

Benzoxazepines constitute a huge number of organic compounds widely described in the
literature. Many of them are distinguished by their biological properties. Among them, our …

Background The role that nc886, a non-coding microRNA, plays in human endometrial
cancer is unknown. The present study aimed to describe the functional role of nc886 in …

Identification of novel anticancer drugs presenting more than one molecular target and
efficacy against cancer stem-like cells (CSCs) subpopulations represents a therapeutic need …

Aim: To develop and characterize bozepinib-loaded lipid-core nanocapsules (BZP-LNC+)
as a potential treatment for glioblastoma (GBM). Methods: Characterization of nanocapsules …