Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
Neuromodulation by the immune system: a focus on cytokines
Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …
mostly in the context of diseases. More recent studies have begun to reveal how certain …
[HTML][HTML] Advances in CRISPR therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
Targeting the NLRP3 inflammasome in inflammatory diseases
MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …
Inflammasome signalling in brain function and neurodegenerative disease
The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …
change in order to store information, but on the other hand is vulnerable to damage from …
Main components of fish immunity: An overview of the fish immune system
DM Mokhtar, G Zaccone, A Alesci, M Kuciel… - Fishes, 2023 - mdpi.com
Cellular immune responses consist of innate and adaptive cell-mediated immune
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
Innate and adaptive immune memory: an evolutionary continuum in the host's response to pathogens
Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …
Origin and functions of tissue macrophages
Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …
homeostasis and disease. Recently, it has become evident that most adult tissue …
Role of innate and adaptive immune mechanisms in cardiac injury and repair
Despite the advances that have been made in develo** new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …
disease remains the leading cause of worldwide mortality. Therefore, understanding the …
The mucosal immune system of teleost fish
I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …