Defining trained immunity and its role in health and disease

MG Netea, J Domínguez-Andrés, LB Barreiro… - Nature Reviews …, 2020 - nature.com
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

Neuromodulation by the immune system: a focus on cytokines

AF Salvador, KA de Lima, J Kipnis - Nature Reviews Immunology, 2021 - nature.com
Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …

[HTML][HTML] Advances in CRISPR therapeutics

M Chavez, X Chen, PB Finn, LS Qi - Nature Reviews Nephrology, 2023 - nature.com
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …

Targeting the NLRP3 inflammasome in inflammatory diseases

MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Inflammasome signalling in brain function and neurodegenerative disease

MT Heneka, RM McManus, E Latz - Nature Reviews Neuroscience, 2018 - nature.com
The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …

Main components of fish immunity: An overview of the fish immune system

DM Mokhtar, G Zaccone, A Alesci, M Kuciel… - Fishes, 2023 - mdpi.com
Cellular immune responses consist of innate and adaptive cell-mediated immune
mechanisms, where all leukocyte subpopulations are included. Among these are vital …

Innate and adaptive immune memory: an evolutionary continuum in the host's response to pathogens

MG Netea, A Schlitzer, K Placek, LAB Joosten… - Cell host & …, 2019 - cell.com
Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …

Origin and functions of tissue macrophages

S Epelman, KJ Lavine, GJ Randolph - Immunity, 2014 - cell.com
Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …

Role of innate and adaptive immune mechanisms in cardiac injury and repair

S Epelman, PP Liu, DL Mann - Nature Reviews Immunology, 2015 - nature.com
Despite the advances that have been made in develo** new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

The mucosal immune system of teleost fish

I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …