Early stage detection and screening of ovarian cancer: A research opportunity and significant challenge for biosensor technology

B De La Franier, M Thompson - Biosensors and Bioelectronics, 2019 - Elsevier
Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality.
Accordingly, it is imperative to detect and diagnose the disease as early as possible in its …

A survey of state-of-the-art surface chemistries to minimize fouling from human and animal biofluids

C Blaszykowski, S Sheikh, M Thompson - Biomaterials science, 2015 - pubs.rsc.org
Upon contact with bodily fluids, synthetic materials spontaneously acquire a layer of various
species (most notably proteins) on their surface. The concern with respect to biomedical …

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

M Xu, J Li, MAD Neves, G Zhu, N Carrim… - Blood, The Journal …, 2018 - ashpublications.org
Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …

Antifouling polymer brushes displaying antithrombogenic surface properties

A de los Santos Pereira, S Sheikh… - …, 2016 - ACS Publications
The contact of blood with artificial materials generally leads to immediate protein adsorption
(fouling), which mediates subsequent biological processes such as platelet adhesion and …

Ceramic membrane with protein-resistant surface via dopamine/diglycolamine co-deposition

N Gao, W Fan, ZK Xu - Separation and Purification Technology, 2020 - Elsevier
Protein separation and purification is important in biotechnology and food processing
industries. Ceramic membranes have shown great potentials for this task. But membrane …

Glucose biosensor based on open-source wireless microfluidic potentiostat

C Mercer, R Bennett, PÓ Conghaile, JF Rusling… - Sensors and Actuators B …, 2019 - Elsevier
Wireless potentiostats capable of cyclic voltammetry and amperometry that connect to the
Internet are emerging as key attributes of future point-of-care devices. This work presents an …

Polymer brushes interfacing blood as a route toward high performance blood contacting devices

F Surman, T Riedel, M Bruns… - Macromolecular …, 2015 - Wiley Online Library
In the current study, well‐defined polymer brushes are shown as an effective surface
modification to resist the adhesion of whole blood and its components. Poly [oligo (ethylene …

On the hydration of subnanometric antifouling organosilane adlayers: A molecular dynamics simulation

S Sheikh, C Blaszykowski, R Nolan… - Journal of colloid and …, 2015 - Elsevier
The connection between antifouling and surface hydration is a fascinating but daunting
question to answer. Herein, we use molecular dynamics (MD) computer simulations to gain …

Wettability tuning of natural rubber/polyvinylpyrrolidone electrospun nonwoven mats

KL Andrade, FL Faita, RM do Nascimento… - Surfaces and …, 2022 - Elsevier
We report here the development of nonwoven electrospun fiber mats containing natural
rubber (NR) and polyvinylpyrrolidone (PVP) blends. NR, PVP, and NR: PVP blended …

Assembling surface linker chemistry with minimization of non-specific adsorption on biosensor materials

JCC Sheng, B De La Franier, M Thompson - Materials, 2021 - mdpi.com
The operation of biosensors requires surfaces that are both highly specific towards the target
analyte and that are minimally subject to fouling by species present in a biological fluid. In …