Safety assessment of pharmaceuticals is a rapidly develo** area of pharmacy and
medicine. The new advanced guidelines for testing the toxicity of compounds require …

We synthesized conjugates of tacrine with 1, 2, 4-thiadiazole derivatives linked by two
different spacers, pentylaminopropene (compounds 4) and pentylaminopropane …

Background Several factors contribute to the development failure of novel pharmaceuticals,
one of the most important being adverse effects in pre-clinical and clinical studies. Early …

A series of previously synthesized conjugates of tacrine and salicylamide was extended by
varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize …

We synthesized eleven new amiridine-piperazine hybrids 5a-j and 7 as potential
multifunctional agents for Alzheimer's disease (AD) treatment by reacting N …

New hybrids of 4-amino-2, 3-polymethylenequinoline with different sizes of the aliphatic ring
linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers …

Permeation through the blood–brain barrier (BBB) is among the most important processes
controlling the pharmacokinetic properties of drugs and other bioactive compounds. Using …

Infectious diseases have held a prominent place in the history of humanity, sha**
societies, influencing medical advances, and affecting the lives of individuals on a global …

The ADMET properties (absorption, distribution, metabolism, excretion, and toxicity) of a
compound are key factors in its success as a drug. While many experimental approaches to …

With the aging of the population intensifying, finding a cure or reasonable treatment for
Alzheimer'disease (AD) has become an urgent priority. To target the multi-facets of AD, a …