Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease
characterized by a progressive decline in lung function. The etiology of IPF is unknown …

Diabetic nephropathy remains a common cause of end-stage renal failure and its associated
mortality around the world. Sphingosine 1-phosphate (S1P) is a multifunctional lipid …

Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

Lipids are major actors and regulators of physiological processes within the lung. Initial
research has described their critical role in tissue homeostasis and in orchestrating cellular …

Background The investigation of lncRNAs has provided a novel perspective for elucidating
mechanisms underlying diverse physiological and pathological processes. Compelling …

Lungs are constantly exposed to environmental perturbations and therefore have
remarkable capacity to regenerate in response to injury. Sustained lung injuries, aging, and …

Endothelial cells (ECs) develop organ-specific gene expression and function in response to
signals from the surrounding tissue. In turn, ECs can affect organ development and …

Resolution of edema remains a significant clinical challenge. Conditions such as traumatic
shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to …