The marine toxins of the Okadaic acid (OA) group are natural compounds produced by
dinoflagellates that enters the food chain by accumulating in seafood. They are responsible …

Simple Summary Preclinical studies evaluating the safety and efficacy of new drugs require
experimental animals, which is important to ensure both adequate dosage and animal …

Specialized pro-resolving mediators (SPMs) have recently emerged as promising
therapeutic approaches for neuropathic pain (NP). We evaluated the effects of oral treatment …

Precise oral dosing in rodents is usually achieved by intragastric gavage. If performed
incorrectly due to technical difficulties, inexperience, or animal resistance, oral gavage may …

Rationale The consequences of perinatal cannabidiol (CBD) exposure are severely
understudied, but are important, given its widespread use and believed safety as a natural …

Simple Summary Carbon dioxide (CO2) inhalation is the most common euthanasia method
for laboratory mice despite causing distress, pain and suffering. Since many laboratories will …

Abstract D-galactose (d-gal) is broadly used in animal aging studies as its chronic
administration mimics learning and memory impairments related to aging in humans …

Drug administration in preclinical rodent models is essential for research and the
development of novel therapies. Compassionate administration methods have been …

Preclinical studies in mice often rely on invasive protocols, such as injections or oral gavage,
to deliver drugs. These stressful routes of administration have significant effects on important …

Voluntary oral drug administration using sweet substances promotes rodents' therapeutic
compliance while reducing stress induced by forced drug administration. We aimed to test …