Mitogen signaling strength and duration can control cell cycle decisions
Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
[HTML][HTML] Cell phenotypes can be predicted from propensities of protein conformations
Proteins exist as dynamic conformational ensembles. Here we suggest that the propensities
of the conformations can be predictors of cell function. The conformational states that the …
of the conformations can be predictors of cell function. The conformational states that the …
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs)
are more prone to develop certain types of cancer. Notably, however, the case statistics can …
are more prone to develop certain types of cancer. Notably, however, the case statistics can …
Molecular principles underlying aggressive cancers
Aggressive tumors pose ultra-challenges to drug resistance. Anti-cancer treatments are
often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still …
often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still …
SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
SHP2 phosphatase promotes full activation of the RTK-dependent Ras/MAPK pathway. Its
mutations can drive cancer and RASopathies, a group of neurodevelopmental disorders …
mutations can drive cancer and RASopathies, a group of neurodevelopmental disorders …
Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing pathways in neurodegenerative disorders and cancer
E3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation
system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) …
system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) …
Slower CDK4 and faster CDK2 activation in the cell cycle
Dysregulation of cyclin-dependent kinases (CDKs) impacts cell proliferation, driving cancer.
Here, we ask why the cyclin-D/CDK4 complex governs cell cycle progression through the …
Here, we ask why the cyclin-D/CDK4 complex governs cell cycle progression through the …
[HTML][HTML] Cancer and autism: how PTEN mutations degrade function at the membrane and isoform expression in the human brain
Mutations causing loss of PTEN lipid phosphatase activity can promote cancer, benign
tumors (PHTS), and neurodevelopmental disorders (NDDs). Exactly how they preferentially …
tumors (PHTS), and neurodevelopmental disorders (NDDs). Exactly how they preferentially …
Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide
The connection and causality between cancer and neurodevelopmental disorders have
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …
been puzzling. How can the same cellular pathways, proteins, and mutations lead to …
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization
mTOR serine/threonine kinase is a cornerstone in the PI3K/AKT/mTOR pathway. Yet, the
detailed mechanism of activation of its catalytic core is still unresolved, likely due to mTOR …
detailed mechanism of activation of its catalytic core is still unresolved, likely due to mTOR …