The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

Abstract Purpose of Review The main goal of this article is to discuss the role of the
epithelial sodium channel (ENaC) in extracellular fluid and blood pressure regulation …

The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for
vertebrate physiology, including the balance of water and sodium ions. It is unclear how its …

Complete or incomplete intestinal obstruction by viscid faecal material in the terminal ileum
and proximal colon–distal intestinal obstruction syndrome (DIOS)–is a common complication …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

The ultrasensitive energy sensor AMP-activated protein kinase (AMPK) orchestrates the
regulation of energy-generating and energy-consuming pathways. AMPK is highly …

Two siblings presented with cardiomyopathy, hypertension, arrhythmia, and fibrosis of the
left atrium. Each had a homozygous null variant in CORIN, the gene encoding atrial …

TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a
condition characterized by alveolar edema. A unique TGF-β pathway is described, which …