Nanomaterials for cancer therapy: current progress and perspectives
Cancer is a disease with complex pathological process. Current chemotherapy faces
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
The uptake of metal–organic frameworks: A journey into the cell
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …
over the past decade, showing huge progress in the development of novel systems …
Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
A historical review of brain drug delivery
WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
Current strategies to enhance delivery of drugs across the blood–brain barrier
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain
K Ogawa, N Kato, M Yoshida, T Hiu, T Matsuo… - Journal of Controlled …, 2022 - Elsevier
Messenger RNA (mRNA) medicine has become a new therapeutic approach owing to the
progress in mRNA delivery technology, especially with lipid nanoparticles (LNP). However …
progress in mRNA delivery technology, especially with lipid nanoparticles (LNP). However …
Recent advances in nanoparticle-based approaches for the treatment of brain tumors: Opportunities and challenges
Malignant brain tumors remain to be highly fatal illnesses with a bleak outlook, as the
average survival rate for patients after receiving medical treatment is less than two years …
average survival rate for patients after receiving medical treatment is less than two years …
Recent advances in drug delivery and targeting to the brain
Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain
The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …
tightly controls the transport of materials between the blood and the brain. There is an …