[HTML][HTML] Lipid peroxidation and antioxidant protection

L Valgimigli - Biomolecules, 2023 - mdpi.com
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological
systems, owing to its interplay with ferroptosis and to its role in secondary damage to other …

Oxidative stability in lipid formulations: a review of the mechanisms, drivers, and inhibitors of oxidation

J Musakhanian, JD Rodier, M Dave - AAPS PharmSciTech, 2022 - Springer
The importance of lipid-based formulations in addressing solubility and ultimately the
bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of …

7-Dehydrocholesterol dictates ferroptosis sensitivity

Y Li, Q Ran, Q Duan, J **, Y Wang, L Yu, C Wang… - Nature, 2024 - nature.com
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …

A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility

PK Morgan, G Pernes, K Huynh, C Giles, S Paul… - Nature Cell …, 2024 - nature.com
The cellular lipidome comprises thousands of unique lipid species. Here, using mass
spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and …

Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

N Yamada, T Karasawa, J Ito, D Yamamuro… - Nature …, 2024 - nature.com
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver
diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we …

Biofortified tomatoes provide a new route to vitamin D sufficiency

J Li, A Scarano, NM Gonzalez, F D'Orso, Y Yue… - Nature Plants, 2022 - nature.com
Poor vitamin D status is a global health problem; insufficiency underpins higher risk of
cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D …

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

FP Freitas, H Alborzinia, AF Dos Santos… - Nature, 2024 - nature.com
Ferroptosis is a form of cell death that has received considerable attention not only as a
means to eradicate defined tumour entities but also because it provides unforeseen insights …

Lipid oxidation in emulsions: New insights from the past two decades

M Hennebelle, P Villeneuve, E Durand… - Progress in Lipid …, 2024 - library.wur.nl
Lipid oxidation constitutes the main source of degradation of lipid-rich foods, including food
emulsions. The complexity of the reactions at play combined with the increased demand …

Free radical lipid peroxidation: mechanisms and analysis

H Yin, L Xu, NA Porter - Chemical reviews, 2011 - ACS Publications
Oxygen is indispensable to metabolism and energy production for almost all life forms.
However, reactive oxygen species (ROS) generated from life processes can cause damage …

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

E Niki - Free Radical Biology and Medicine, 2014 - Elsevier
Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved
with an elaborate defense network against oxidative stress, in which multiple antioxidant …