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[HTML][HTML] Lipid peroxidation and antioxidant protection
L Valgimigli - Biomolecules, 2023 - mdpi.com
Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological
systems, owing to its interplay with ferroptosis and to its role in secondary damage to other …
systems, owing to its interplay with ferroptosis and to its role in secondary damage to other …
Oxidative stability in lipid formulations: a review of the mechanisms, drivers, and inhibitors of oxidation
The importance of lipid-based formulations in addressing solubility and ultimately the
bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of …
bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of …
7-Dehydrocholesterol dictates ferroptosis sensitivity
Y Li, Q Ran, Q Duan, J **, Y Wang, L Yu, C Wang… - Nature, 2024 - nature.com
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
The cellular lipidome comprises thousands of unique lipid species. Here, using mass
spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and …
spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and …
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver
diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we …
diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we …
Biofortified tomatoes provide a new route to vitamin D sufficiency
Poor vitamin D status is a global health problem; insufficiency underpins higher risk of
cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D …
cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D …
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
FP Freitas, H Alborzinia, AF Dos Santos… - Nature, 2024 - nature.com
Ferroptosis is a form of cell death that has received considerable attention not only as a
means to eradicate defined tumour entities but also because it provides unforeseen insights …
means to eradicate defined tumour entities but also because it provides unforeseen insights …
Lipid oxidation in emulsions: New insights from the past two decades
Lipid oxidation constitutes the main source of degradation of lipid-rich foods, including food
emulsions. The complexity of the reactions at play combined with the increased demand …
emulsions. The complexity of the reactions at play combined with the increased demand …
Free radical lipid peroxidation: mechanisms and analysis
Oxygen is indispensable to metabolism and energy production for almost all life forms.
However, reactive oxygen species (ROS) generated from life processes can cause damage …
However, reactive oxygen species (ROS) generated from life processes can cause damage …
Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence
E Niki - Free Radical Biology and Medicine, 2014 - Elsevier
Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved
with an elaborate defense network against oxidative stress, in which multiple antioxidant …
with an elaborate defense network against oxidative stress, in which multiple antioxidant …