DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …

Incorporation of polymer chain entanglements within a single network can synergistically
improve stiffness and toughness, yet attaining such dense entanglements through vat …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …

Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Biological barriers are multicellular structures that precisely regulate the transport of ions,
biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical …

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …