Late-stage functionalization for improving drug-like molecular properties
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
The emergence of the C–H functionalization strategy in medicinal chemistry and drug discovery
R Jana, HM Begam, E Dinda - Chemical Communications, 2021 - pubs.rsc.org
Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …
discovery is an important criterion for successful implementation. Despite the rapid ascent of …
Transition-metal-catalyzed silylation and borylation of C–H bonds for the synthesis and functionalization of complex molecules
The functionalization of C–H bonds in organic molecules containing functional groups has
been one of the holy grails of catalysis. One synthetically important approach to the diverse …
been one of the holy grails of catalysis. One synthetically important approach to the diverse …
CH Borylation: A Toolbox for Molecular Diversification
Iridium-catalyzed C–H activation and borylation has become as a powerful synthetic tool in
the past few decades because of the widespread applicability and versatility of organoboron …
the past few decades because of the widespread applicability and versatility of organoboron …
Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development
M Xu, Z Bai, B **e, R Peng, Z Du, Y Liu, G Zhang… - Molecules, 2024 - mdpi.com
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through
multiple mechanisms. Comprehensive research has shown that the development success …
multiple mechanisms. Comprehensive research has shown that the development success …
Enantioselective Total Syntheses of Vallesamidine and Schizozygane Alkaloids
A general streamlined strategy for the enantioselective total syntheses of the schizozygane
family of natural products and related alkaloid vallesamidine is described. Specifically, a …
family of natural products and related alkaloid vallesamidine is described. Specifically, a …
Sequential Metal Catalysis towards 7‐Oxostaurosporine and Its Non‐Natural Septanose Analogue
K Seo, SH Jang, YH Rhee - Angewandte Chemie International …, 2022 - Wiley Online Library
We report sequential metal catalysis towards indolocarbazole glycosides. The signature
event is highlighted by i) Pd0‐catalyzed addition of indolocarbazole to alkoxyallene …
event is highlighted by i) Pd0‐catalyzed addition of indolocarbazole to alkoxyallene …
A multicomponent reaction for modular assembly of indole-fused heterocycles
Indoles are privileged chemical entities in natural products and drug discovery. Indole-fused
heterocycles, particularly seven-membered ones, have received increasing attention due to …
heterocycles, particularly seven-membered ones, have received increasing attention due to …
Selenylation/Cyclization of 1‐(2‐(Allyloxy) aryl)‐1H‐indoles Access to Seleno‐Benzo [2, 3][1, 4] oxazepino [4, 5‐a] indole Derivatives
H Liao, M Pan, H Zhao, Y Qian, J Liu… - … Synthesis & Catalysis, 2025 - Wiley Online Library
Abstract The iron (ІІІ)‐promoted tandem cyclization of 1‐(2‐(allyloxy) aryl)‐1H‐indoles with
diselenides has been developed for the preparation of seleno‐benzo [2, 3][1, 4] oxazepino …
diselenides has been developed for the preparation of seleno‐benzo [2, 3][1, 4] oxazepino …
Effective Targeting of Epithelial Mesenchymal Transition-Driven Breast Cancer Stem Cells Using Ophiobolin A, A Natural Product
K Reisenauer - 2021 - search.proquest.com
Triple negative breast cancer (TNBC) is characterized by the lack of progesterone and
estrogen hormone receptors and lack of HER2 overexpression, resulting in limited treatment …
estrogen hormone receptors and lack of HER2 overexpression, resulting in limited treatment …