Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Review of recent advances on post-translational modifications that determine the role of
HMGB1 as a cytokine mediator. HMGB1 is a ubiquitous nuclear protein present in almost all …

HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

The activation of innate immune responses by nucleic acids is crucial to protective and
pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) …

Immunogenic profile of certain cancer cell death mechanisms has been transmuted by
research published over a period of last few years and this change has been so drastic that …

The orderly progression of most DNA-related activities such as transcription, replication,
recombination, and repair involves changes in the structure of the DNA and in the …

Abstract High mobility group 1 (HMG1) protein is an abundant component of all mammalian
nuclei, and related proteins exist in all eukaryotes 1, 2. HMG1 binds linear DNA with …

High‐mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear
functions and extracellular cytokine‐like effects. In this report, we study possible candidate …

High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine
when released in the extracellular milieu by necrotic and inflammatory cells. Here, we show …