Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

Structural proteomics refers to large‐scale map** of protein structures in order to
understand the relationship between protein sequence, structure, and function. Chemical …

Covalent labeling with mass spectrometry is increasingly being used for the structural
analysis of proteins. Diethylpyrocarbonate (DEPC) is a simple to use, commercially …

Diethylpyrocarbonate (DEPC) covalent labeling-mass spectrometry (CL-MS) has been
extensively utilized to study protein structure and interactions owing to its ease of use …

Diethylpyrocarbonate (DEPC) labeling analyzed with mass spectrometry can provide
important insights into higher order protein structures. It has been previously shown that …

Membrane-associated proteins are important because they mediate interactions between a
cell's external and internal environment and they are often targets of therapeutics …

Specific amino acid footprinting mass spectrometry (MS) is an increasingly utilized method
for elucidating protein higher order structure (HOS). It does this by adding to certain amino …

Hydrogen–deuterium exchange (HDX) mass spectrometry (MS) and covalent labeling (CL)
MS are typically considered to be complementary methods for protein structural analysis …

Identifying changes in the higher-order structure (HOS) of therapeutic monoclonal
antibodies upon storage, stress, or mishandling is important for ensuring efficacy and …

Antigen–antibody epitope map** is essential for understanding binding mechanisms and
develo** new protein therapeutics. In this study, we investigate diethylpyrocarbonate …