[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies

H Sutanto, A Lyon, J Lumens, U Schotten… - Progress in biophysics …, 2020 - Elsevier
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Atrial fibrillation and type 2 diabetes: prevalence, etiology, pathophysiology and effect of anti‐diabetic therapies

DSH Bell, E Goncalves - Diabetes, Obesity and Metabolism, 2019 - Wiley Online Library
New‐onset atrial fibrillation (NAF) is increased in the type 2 diabetic patient because of the
presence of the metaboli syndrome and increased sympathetic activity. This results in …

Preventive and therapeutic role of functional ingredients of barley grass for chronic diseases in human beings

Y Zeng, X Pu, J Yang, J Du, X Yang, X Li… - Oxidative medicine …, 2018 - Wiley Online Library
Barley grass powder is the best functional food that provides nutrition and eliminates toxins
from cells in human beings; however, its functional ingredients have played an important …

Emerging antiarrhythmic drugs for atrial fibrillation

A Saljic, J Heijman, D Dobrev - International Journal of Molecular …, 2022 - mdpi.com
Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …

Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications

T Liu, T Li, D Xu, Y Wang, Y Zhou… - … of the Royal …, 2023 - royalsocietypublishing.org
Ca2+-activated K+ channels are critical to cellular Ca2+ homeostasis and excitability; they
couple intracellular Ca2+ and membrane voltage change. Of these, the small, 4–14 pS …

Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2

RL Woltz, Y Zheng, W Choi, K Ngo, P Trinh… - Proceedings of the …, 2024 - pnas.org
Small-conductance Ca2+-activated K+ channels (SK, KCa2) are gated solely by intracellular
microdomain Ca2+. The channel has emerged as a therapeutic target for cardiac …

Pathophysiological and therapeutic implications in patients with atrial fibrillation and heart failure

F Hohendanner, FR Heinzel, F Blaschke, BM Pieske… - Heart failure …, 2018 - Springer
Heart failure and atrial fibrillation are common and responsible for significant mortality of
patients. Both share the same risk factors like hypertension, ischemic heart disease …

[HTML][HTML] Antiarrhythmic drugs for atrial fibrillation: imminent impulses are emerging

GA Dan, D Dobrev - IJC heart & vasculature, 2018 - Elsevier
Rhythm and rate strategies are considered equivalent for the management of atrial
fibrillation (AF). Moreover, both strategies are intended for improving symptoms and quality …

Aquaporin channels in the heart—physiology and pathophysiology

AO Verkerk, EM Lodder, R Wilders - International journal of molecular …, 2019 - mdpi.com
Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of
cells and tissues throughout the body. They are known as water channels, but they also …

Atria-selective antiarrhythmic drugs in need of alliance partners

R Peyronnet, U Ravens - Pharmacological Research, 2019 - Elsevier
Atria-selective antiarrhythmic drugs in need of alliance partners. Guideline-based treatment
of atrial fibrillation (AF) comprises prevention of thromboembolism and stroke, as well as …