Decision-support challenges in the chemical-pharmaceutical industry: Findings and future research directions

CM Marques, S Moniz, JP de Sousa… - Computers & Chemical …, 2020 - Elsevier
The chemical-pharmaceutical sector is facing an unprecedented fast-changing environment,
with new market and technological trends impacting the companies' operational strategies …

Model predictive control in pharmaceutical continuous manufacturing: A review from a user's perspective

M Jelsch, Y Roggo, P Kleinebudde… - European Journal of …, 2021 - Elsevier
Pharmaceutical continuous manufacturing is considered as an emerging technology by the
regulatory agencies, which have defined a framework guided by an effective quality risk …

[HTML][HTML] An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US

AC Fisher, W Liu, A Schick, M Ramanadham… - International journal of …, 2022 - Elsevier
Continuous manufacturing (CM) sends materials directly and continuously to the next step of
a process, eliminating hold times and reducing processing times. The potential benefits of …

Continuous flow synthesis of ordered porous materials: from zeolites to metal–organic frameworks and mesoporous silica

Z Liu, J Zhu, C Peng, T Wakihara… - Reaction Chemistry & …, 2019 - pubs.rsc.org
Ordered porous materials are a class of materials featuring a well-defined framework that
forms nanometer-sized channels and cages. Prominent examples of ordered porous …

Research landscape analysis for quality in Pharma 4.0 era

RV Barenji, RE Hariry, D Demirkol, TU Daim - Technology in Society, 2024 - Elsevier
This study focuses on the production phase of drug development and examines approaches
and their progress indicators for enhancing the quality of pharmaceutical products and …

Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

C Sampat, L Kotamarthy, P Bhalode… - Journal of Advanced …, 2022 - Wiley Online Library
The global pharmaceutical industry is a trillion‐dollar market. However, the pharmaceutical
sector often lags in manufacturing innovation and automation which limits its potential to …

The Rocky Road From Fed-Batch to Continuous Processing With E. coli

J Kopp, C Slouka, O Spadiut, C Herwig - Frontiers in Bioengineering …, 2019 - frontiersin.org
Escherichia coli still serves as a beloved workhorse for the production of many
biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times …

An integrated data management and informatics framework for continuous drug product manufacturing processes: A case study on two pilot plants

Y Chen, C Sampat, YS Huang, S Ganesh… - International Journal of …, 2023 - Elsevier
The pharmaceutical industry continuously looks for ways to improve its development and
manufacturing efficiency. In recent years, such efforts have been driven by the transition from …

[HTML][HTML] A large-scale experimental comparison of batch and continuous technologies in pharmaceutical tablet manufacturing using ethenzamide

K Matsunami, T Nagato, K Hasegawa… - International journal of …, 2019 - Elsevier
This paper compares batch and continuous technologies in terms of product quality and
process performance in pharmaceutical tablet manufacturing using ethenzamide as the …

Application of continuous manufacturing for solid oral dosage forms

EA Jung, YJ Park, JE Kim - Journal of Pharmaceutical Investigation, 2023 - Springer
Background Continuous manufacturing, a new process that applies the concept of time
rather than batch size, is gradually being implemented throughout the pharmaceutical …