Counteracting colon cancer by inhibiting mitochondrial respiration and glycolysis with a selective PKCδ activator

C Bessa, JB Loureiro, M Barros, VMS Isca… - International Journal of …, 2023 - mdpi.com
Metabolic reprogramming is a central hub in tumor development and progression.
Therefore, several efforts have been developed to find improved therapeutic approaches …

Metabolic reprogramming contributes to radioprotection by protein kinase Cδ

AM Ohm, T Affandi, JA Reisz, MC Caino… - Journal of Biological …, 2023 - ASBMB
Loss of protein kinase Cδ (PKCδ) activity renders cells resistant to DNA damaging agents,
including irradiation; however, the mechanism (s) underlying resistance is poorly …

Protein kinase C delta mediates Pasireotide effects in an ACTH-secreting pituitary tumor cell line

E Gentilin, P Borges De Souza, MR Ambrosio… - Journal of …, 2023 - Springer
Purpose Clinical control of corticotroph tumors is difficult to achieve since they usually
persist or relapse after surgery. Pasireotide is approved to treat patients with Cushing's …