Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Highlights•New therapeutic strategies are moving towards nanomedicine and the use of
innovative drug delivery systems to release drugs within the joint.•Ethical considerations …

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering
approaches are primarily based on collagen type I devices that are associated with …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

Rheumatoid arthritis (RA) seriously impairs the quality of life of sufferers. It has been shown
that Lycium barbarum polysaccharide (LBP), a natural active indigestible ingredient with …

Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

Background Scales are mineralised exoskeletal structures that are part of the dermal
skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony …