Mammalian aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that
belongs to the basic helix–loop–helix (bHLH)–PAS family of transcription factors, which are …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

Abstract Poly (ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …

PARP-7 (TiPARP) is a mono (ADP-ribosyl) transferase whose protein substrates and
biological activities are poorly understood. We observed that PARP7 mRNA levels are lower …

The aryl hydrocarbon receptor (AHR) has been studied for over 40 years, yet our
understanding of this ligand-activated transcription factor remains incomplete. Each year …

Here, we report the biochemical characterization of the mono-ADP-ribosyltransferase 2, 3, 7,
8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase (TIPARP/ARTD14/PARP7) …

Objective The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor
regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands …

Abstract Poly-(ADP)-ribose polymerases (PARPs) are a family of 17 enzymes in humans that
have diverse roles in cell physiology including DNA damage repair, transcription, innate …

Aging, a complex biological process, plays key roles the development of multiple disorders
referred as aging-related diseases involving cardiovascular diseases, stroke …