Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Centromeres direct chromosome inheritance, but in multicellular organisms their positions
on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The …

Wide crosses result in postzygotic elimination of one parental chromosome set, but the
mechanisms that result in such differential fate are poorly understood. Here, we show that …

The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to
cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute …

The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by
preventing cell division when chromosomes are not correctly attached to the spindle …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Fidelity during chromosome segregation is essential to prevent aneuploidy. The proteins
and chromatin at the centromere form a unique site for kinetochore attachment and allow the …

Equal distribution of DNA in mitosis requires the assembly of a large proteinaceous
ensemble onto the centromeric DNA, called the kinetochore. With few exceptions …

Background The histone H3 variant CENP-A is normally tightly regulated to ensure only one
centromere exists per chromosome. Native CENP-A is often found overexpressed in human …