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mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
Accelerated COVID-19 vaccine development: milestones, lessons, and prospects
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …
Efficacy and safety of an mRNA-based RSV PreF vaccine in older adults
Background Respiratory syncytial virus (RSV) can cause substantial morbidity and mortality
among older adults. An mRNA-based RSV vaccine, mRNA-1345, encoding the stabilized …
among older adults. An mRNA-based RSV vaccine, mRNA-1345, encoding the stabilized …
Durability of neutralizing RSV antibodies following nirsevimab administration and elicitation of the natural immune response to RSV infection in infants
D Wilkins, Y Yuan, Y Chang, AA Aksyuk, BS Núñez… - Nature Medicine, 2023 - nature.com
Nirsevimab is an extended half-life monoclonal antibody specific for the prefusion
conformation of the respiratory syncytial virus (RSV) F protein, which has been studied in …
conformation of the respiratory syncytial virus (RSV) F protein, which has been studied in …
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …
Prefusion F protein–based respiratory syncytial virus immunization in pregnancy
EAF Simões, KJ Center, ATN Tita… - … England Journal of …, 2022 - Mass Medical Soc
Background Respiratory syncytial virus (RSV), a major cause of illness and death in infants
worldwide, could be prevented by vaccination during pregnancy. The efficacy …
worldwide, could be prevented by vaccination during pregnancy. The efficacy …
[HTML][HTML] Respiratory syncytial virus vaccines: a review of the candidates and the approved vaccines
Respiratory syncytial virus (RSV) is responsible for a significant proportion of global
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …
Structural insights into coronavirus entry
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …
Vaccines for COVID-19
JS Tregoning, ES Brown… - Clinical & …, 2020 - academic.oup.com
Since the emergence of COVID-19, caused by the SARS-CoV-2 virus at the end of 2019,
there has been an explosion of vaccine development. By 24 September 2020, a staggering …
there has been an explosion of vaccine development. By 24 September 2020, a staggering …
Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine
Y Che, AV Gribenko, X Song, LD Handke… - Science Translational …, 2023 - science.org
Respiratory syncytial virus (RSV) is the leading, global cause of serious respiratory disease
in infants and is an important cause of respiratory illness in older adults. No RSV vaccine is …
in infants and is an important cause of respiratory illness in older adults. No RSV vaccine is …