The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

TJ Littlejohns, J Holliday, LM Gibson, S Garratt… - Nature …, 2020‏ - nature.com
UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …

Advanced body composition assessment: from body mass index to body composition profiling

M Borga, J West, JD Bell, NC Harvey… - Journal of …, 2018‏ - journals.sagepub.com
This paper gives a brief overview of common non-invasive techniques for body composition
analysis and a more in-depth review of a body composition assessment method based on …

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

Y Liu, N Basty, B Whitcher, JD Bell, EP Sorokin… - elife, 2021‏ - elifesciences.org
Cardiometabolic diseases are an increasing global health burden. While socioeconomic,
environmental, behavioural, and genetic risk factors have been identified, a better …

BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases

S Agrawal, MDR Klarqvist, N Diamant… - Nature …, 2023‏ - nature.com
For any given body mass index (BMI), individuals vary substantially in fat distribution, and
this variation may have important implications for cardiometabolic risk. Here, we study …

Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled …

IJ Neeland, SP Marso, CR Ayers, B Lewis… - The lancet Diabetes & …, 2021‏ - thelancet.com
Background Visceral and ectopic fat are key drivers of adverse cardiometabolic outcomes in
obesity. We aimed to evaluate the effects of injectable liraglutide 3· 0 mg daily on body fat …

[HTML][HTML] Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art

K Engelke, O Chaudry, L Gast, MAB Eldib… - Journal of orthopaedic …, 2023‏ - Elsevier
Background Magnetic resonance imaging (MRI) is the dominant 3D imaging modality to
quantify muscle properties in skeletal muscle disorders, in inherited and acquired muscle …

Body composition profiling in the UK Biobank Imaging Study

J Linge, M Borga, J West, T Tuthill, MR Miller… - …, 2018‏ - Wiley Online Library
Objective This study aimed to investigate the value of imaging‐based multivariable body
composition profiling by describing its association with coronary heart disease (CHD), type 2 …

A systematic review of automated segmentation of 3D computed‐tomography scans for volumetric body composition analysis

DVC Mai, I Drami, ET Pring, LE Gould… - Journal of Cachexia …, 2023‏ - Wiley Online Library
Automated computed tomography (CT) scan segmentation (labelling of pixels according to
tissue type) is now possible. This technique is being adapted to achieve three‐dimensional …

Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study

TP Gurholt, MG Borda, N Parker… - Brain …, 2024‏ - academic.oup.com
Sarcopenia refers to age-related loss of muscle mass and function and is related to impaired
somatic and brain health, including cognitive decline and Alzheimer's disease. However, the …

Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published …

S Iliodromiti, J McLaren, N Ghouri, MR Miller… - Diabetologia, 2023‏ - Springer
Abstract Aims/hypothesis South Asians have a two-to fivefold higher risk of develo** type
2 diabetes than those of white European descent. Greater central adiposity and storage of …