MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the
past 5 years. This article summarizes data from collaborative group and institutional trials …

Three histological variants are known within the family of embryonal rosette-forming
neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Embryonal tumors with multilayered rosettes (ETMRs) are rare, deadly pediatric brain
tumors characterized by high-level amplification of the microRNA cluster C19MC,. We …

Wnt is a complex signaling pathway involved in the regulation of crucial biological functions
such as development, proliferation, differentiation and migration of cells, mainly stem cells …

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been
linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising …